Characterizing self-assembled nanoparticles employed in durg delivery

Kazuo Sakurai(University of Kitakyushu, Japan)

The potential of supramolecular self-assembly to produce sophisticated structures and functions has attracted significant attention to the systems The driving forces for such supramolecular self-assembly consist of multiple anisometric inter- and intra-molecular interactions, including hydrophobic, van der Waals, electrostatic, and π-π interactions. Individually, each interaction is subtle and insignificant but their combination and balance essentially determine the assembled structures. This chemistry offers diverse techniques to design nanoparticles employed for drug delivery systems (DDSs). Characterizing the inner structures of such particles is essentially important. This presentation reviews our recent studies on such issue, focusing on polymeric micelles for anti-cancer delivery, cationic micelles for gene delivery, and a polysaccharide carrier for siRNA. One of our final goals is to visualize their inner structures by combining small angle X-ray scattering and light scattering coupled with separation technique.

References Yusuke Sanada et al., J. Phys. Chem. B in press, 2012. Shota Fujii et al., Langmuir, 2012, 28 (6), pp 3092-3101. Yusuke Sanada et al., J. Phys. Chem. B, 2012, 116 (1), pp 87-94. Shinichi Mochizuki and Kazuo Sakurai. J. Controlled Release. 151(2), 2011, 155-161. Isam Akiba et al., Langmuir, 2010, 26, 7544-7551

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